ABSTRACT
OBJECTIVE: To explore a research path and statistical analytical method for cost-utility analysis suitable for gallstone surgery patients.METHODS: A decision-making model for the treatment of cholelithiasis surgery was established;the costs(C) and utility values at each nodal point(? U) were collected,with the results subjected to sensitivity analysis and threshold analysis.RESULTS: The cost-utility ratios(CUR) of laparoscopic operation and open surgery were 4 605.6(? 30%) yuan/QALY and 5 979.7(? 30%) yuan/QALY,respectively.One dimension sensitivity analysis of each( every) parameter reveals that the former CUR value is greater than the latter one.C1 and ? U1 showed the biggest impact on the CUR of laparoscopic operation,while C5 and ? U5 did on the CUR of open surgery.When C1=10 205.6 yuan,or ? U1=1.303 or C5=10 979.8 yuan or ? U5=3.095,CUR of laparoscopic operation was equal to CUR of open surgery,which means that the conversion of threshold was achieved.CONCLUSION: The designed research path and statistic analytic methods are suitable for the cost-utility analysis of cholelithiasis surgery patients.
ABSTRACT
OBJECTIVE:To prepare phloroglucinol for injection,establish its quality control and determine its stability.METHODS:The type and dosage of the adjuvant in the formula were optimized and the phloroglucinol for injection was prepared,with its content determined by HPLC.Meanwhile its stability was tested.RESULTS:Mannitol 100.0g was determined as the adjuvant in the formula.The linear range of phloroglucinol was 0.13～ 1.04mg.mL-1(r=1.000 0).No obvious changes were observed at 6 month of an accelerated test or 12 month of long-term storage test.CONCLUSIONS:The preparation is reasonable and feasible in techniques,controllable and stable in quality;and the established method is recurrent,specific and the determination results are within defined margin.